BioSeed®-C an autologous cartilage graft for osteoarthritis: stable 4 years on

 

Kreuz, Peter C. et al. ; available online http://arthritis-research.com/content/11/2/R33

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NEWSLETTER    Vol. 03/2009, July

The results of this observational case-report study suggest that chondrocyte-based cartilage transplants have the potential to treat not only small traumatic defects but large focal degenerative defects of cartilage.This approach allows effective cartilage repair even in defects that lack intact cartilage surrounding the defect and can close the gap between initial surgical interventions such as lavage or debridement and total joint replacement.

 

Fig.1: Magnetic resonance (MRI) before and 4 years after implantation of BioSeed®-C. (a) Preoperative cartilage defect (encircled) at the femoral condyle. (b) After 4 years, complete defect filling (c) Preoperative patellar cartilage defect (encircled) that was completely filled after implantation of the graft at 4 years (d).

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We would like to introduce you our most recent publication from Kreuz, P.C. et al. published in Arthritis Research & Therapy in 2009.

The paper reports on the four year clinical results after treatment of focal degenerative cartilage defects with BioSeed®-C, a polymer-based autologous chondrocyte graft.

Bioseed®-C was performed in 19 patients with preoperative radiographic and clinical signs of osteoarthritis. The chondrocytes, taken from healthy cartilage in a non-weight-bearing area of the knee, were transplanted into areas of focal degenerative defects.

Clinical effects measured by using the Lysholm score, the Knee injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee (IKDC) score and the International Cartilage Repair Society (ICRS) Score were observed as soon as 6 months after the procedure and outcomes were significantly improved from baseline after 1 year. The benefits were still evident at 4 years and included improvements in quality of life and pain. MRI analysis of those two patients at 1 year showed only partial (<50%) filling of the defect with repair cartilage and articular resurfacing. By contrast, MRI in the other 17 patients demonstrated moderate-to complete defect filling at 4 years (Fig.1).